Affinity at one of the serotonin receptors causes weight gain, a side effect more predominant in clozapine than risperidone than haloperidol. Which receptor is responsible for this effect?
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The primary serotonin receptor associated with weight gain is the 5-HT2C receptor. Show more…
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Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with receptors (5-HT receptors) located in cells throughout the body. There are more than a dozen different types of serotonin receptors that fall into several different classes. One class consists of serotonin-activated ion channels and the other receptor classes are G-protein-coupled receptors that associate with different G proteins. The 5-HT7A receptor couples to Gs and activates adenylyl cyclase, while the 5-HT2B receptor couples to Gq and activates phospholipase C. The diversity of receptor types has led pharmacologists to search for drugs that will bind to and modulate just a single receptor class in order to limit systemic side effects (see 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials). Place into bins the downstream effects predicted for a drug that exclusively activates the 5-HT7A receptor versus a drug that exclusively activates the 5-HT2B receptor. Items (5 items) (Drag and drop into the appropriate area below) Cytosolic calcium increase PKC activation PKA activation cAMP production IP3 production Receptor subtype 5-HT7A 5-HT2B
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