After extended periods of exercise in the fasted state but in the presence of abundant oxygen: Muscle tissues break down protein by proteasomal degradation, directly producing ATP Muscle tissues break down protein and converts the resulting amino acids to alanine and alpha ketoacids by transamination of pyruvate Muscle tissues breaks down protein by receptor-mediated endocytosis, directly producing ATP Muscle tissues synthesize their own glucose by gluconeogenesis to fuel ATP synthesis Muscle tissues break down stored glycogen to pyruvate that is then reduced to lactic acid
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During exercise when the body lacks an adequate supply of oxygen to support energy production, the pyruvate that is produced from the breakdown of glucose is converted into lactate. High lactate levels can lead to acidity in the muscle cells as some of the lactate hydrolyzes to lactic acid. The dissociation of lactic acid to lactate is shown in the reaction. Lactic acid has a pKa of 3.86. A solution containing a mixture of lactic acid and lactate was found to have a pH of 4.41. Calculate the ratio of the lactate concentration to the lactic acid concentration in this solution. [lactate] / [lactic acid] = 1.74
Sri K.
vIf you are lifting a very heavy weight, your muscle contraction cuts off the blood supply so there's no oxygen available to your muscle. luckily, muscle has glycogen and this allows for a glucose source. In order to make ATP, the muscle undergoes alcoholic fermentation . pyruvate acts as a terminal electron acceptor in order to regenerate NAD+ .
Jenny W.
Role of Lactate Dehydrogenase During strenuous activity, the demand for ATP in muscle tissue is vastly increased. In rabbit leg muscle or turkey flight muscle, the ATP is produced almost exclusively by lactic acid fermentation. ATP is formed in the payoff phase of glycolysis by two reactions, promoted by phosphoglycerate kinase and pyruvate kinase. Suppose skeletal muscle were devoid of lactate dehydrogenase. Could it carry out strenuous physical activity; that is, could it generate ATP at a high rate by glycolysis? Explain.
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