Question

All amino acids have two ionizable functional groups: an ?-amino group (average pK? of 9.4) and an ?-carboxylic acid group (average pK? of 2.2). Histidine also has an ionizable side chain (R group) with a pK? of about 6.0. One of the possible ionization states of histidine is shown in the image. At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups. The protonated form of the R group of histidine is shown in the structure. The ratio of the charged (protonated) form to the deprotonated form depends on the pK? of the R group and the pH of the solution. Select the pH values at which the charged form of the R group would predominate. 11.1 4.0 4.9 6.0

          All amino acids have two ionizable functional groups: an ?-amino group (average pK? of 9.4) and an ?-carboxylic acid group (average pK? of 2.2). Histidine also has an ionizable side chain (R group) with a pK? of about 6.0. One of the possible ionization states of histidine is shown in the image.

At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups.

The protonated form of the R group of histidine is shown in the structure. The ratio of the charged (protonated) form to the deprotonated form depends on the pK? of the R group and the pH of the solution.

Select the pH values at which the charged form of the R group would predominate.

11.1
4.0
4.9
6.0

All amino acids have two ionizable functional groups: an ?-amino group (average pK? of 9.4) and an ?-carboxylic acid group (average pK? of 2.2). Histidine also has an ionizable side chain (R group) with a pK? of about 6.0. One of the possible ionization states of histidine is shown in the image.

At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups.

The protonated form of the R group of histidine is shown in the structure. The ratio of the charged (protonated) form to the deprotonated form depends on the pK? of the R group and the pH of the solution.

Select the pH values at which the charged form of the R group would predominate.

11.1
4.0
4.9
6.0

Added by Deborah B.

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