All of the statements describe profilin association with actin EXCEPT: profilin binds to G-actin away from the nucleotide binding site. profilin stimulates the release of ADP from G-actin. profilin binds to ATP and assists with its binding to G-actin. profilin prevents association of the monomer with the - end of F-actin. Actually, all of these describe profiling association with actin.
Added by Donald R.
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Step 1: Profilin is a protein that binds to actin monomers and promotes the assembly of actin filaments. Show more…
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Which of the following statements does NOT correctly match an actin-binding protein with its function? A. Cofilin binds to F-actin B. Profilin acts as a GTPase-activating protein (GAP) for G-actin C. The Arp2/3 protein complex nucleates the assembly of branched actin D. CapZ binds to the ends of actin filaments, preventing subunit addition or loss
Marlyn J.
Cofilin binds preferentially to G-actin-ADP, rather than G-actin-ATP in a microfilament. This has the following effect: This causes tight binding between actin microfilaments This causes hydrolysis of ATP bound to G actin This causes newer microfilament to destabilize This causes older microfilament to destabilize
Adi S.
ACTIN FILAMENT BINDING PROTEINS (over 100!) CHARACTERISTICS DRAWING High Concentration RESULTS Binds Actin monomers and "locks" them. Cannot associate with either end of Filament. Thymosin No Actin Filament formation. Binds to Actin monomers and blocks addition to minus end only. Competes with thymosin for monomer binding. Profilin Growth at plus end only. Nucleates growth from the minus end. Can nucleate formation of a branch. Occurs primarily at Plasma membrane. Can Cap minus end. ARP 2/3 Nucleates growth at the plus end. Occurs primarily at Plasma membrane. Formin Tropomyosin Tropomodulin Binds the side of a filament. Stabilizes and Stiffens. Prevents interactions with other proteins. Caps minus ends of tropomyosin stabilized filaments. Dimer with high affinity for the plus ends of actin filaments. CapZ inhibited by the LIPID PI(4,5)P2 Stabilizes + end. No growth, no dissociation at plus end. Near membrane CapZ inhibited. CapZ Actin severing protein. Activated by high cytosolic Ca++. Gelsolin Actin depolymerizing protein. Prefers ADP-actin filaments. Cofilin
Sri K.
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