$$\alpha$$-Ketoglutarate plays a central role in the biosynthesis of several amino acids. Arrange the reactions to outline the net synthesis of $$\alpha$$-ketoglutarate from pyruvate. Your proposed sequence must not include reactions that result in the net consumption of other citric acid cycle intermediates.
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This implies that any citric acid cycle intermediates used must be regenerated. This is a classic anaplerotic pathway problem. The overall reaction we want to achieve is: Pyruvate $\rightarrow$ $\alpha$-Ketoglutarate Let's break down the steps involved in Show more…
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$\alpha$ -Ketoglutarate plays a central role in the biosynthesis of several amino acids. Write a sequence of enzymatic reactions that could result in the net synthesis of $\alpha$ -ketoglutarate from pyruvate. Your proposed sequence must not involve the net consumption of other citric acid cycle intermediates. Write an equation for the overall reaction and identify the source of each reactant.
The amino acid glutamate is synthesized from a-ketoglutarate, a catalytic intermediate in the citric acid cycle. In order for glutamate to be synthesized without depleting citric acid cycle intermediates, more carbon must be added to the cycle to make excess a-ketoglutarate. a. Describe the net synthesis of a-ketoglutarate from methyl labelled pyruvate in which no citric acid cycle intermediates are depleted. You must show how pyruvate can be used as a starting material to synthesize two a-ketoglutarate molecules by introducing more carbons into the citric acid cycle than are lost (don't overlook CO2). b. Show the position(s) of the label from pyruvate in the a-ketoglutarate produced.
Sri K.
It is possible, with the use of the reactions and enzymes considered in this chapter, to convert pyruvate into $\alpha$ -ketoglutarate without depleting any of the citric acid cycle components. Write a balanced reaction scheme for this conversion, showing cofactors and identifying the required enzymes.
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