Alternative splicing helps to explain the large number of genes in the human genome. why different proteins can be made from the same genes. the great variety in protein modifications. the origins of microRNAs. why there are fewer mRNAs than there are human genes.
Added by Richard L.
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Alternative splicing is a process that occurs during gene expression, where a single gene can produce multiple mRNA transcripts (and subsequently proteins) by including or excluding certain exons within the pre-mRNA. This process allows for a greater diversity of Show more…
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Alternative splicing is present in about 90% of human genes and can explain why our 20,325 genes can encode more than 1,000,000 proteins. Examine the image below of Gene X: Exon A Intron #1 Exon B Intron #2 Exon C 1. (2 pts) To create a transcript, which portions of this DNA sequence would be REMOVED during splicing? (Please be specific - ie. Exon A, Intron #2, etc.) 2. (3 pts) Gene X can encode 7 different proteins! Explain how this is possible by describing at least 3 examples of the different proteins that could be produced from Gene X.
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Alternative splicing is a common mechanism for eukaryotes to expand their repertoire of gene functions. At least one estimate indicates that approximately 50 percent of human genes use alternative splicing, and approximately 15 percent of disease causing mutations involve aberrant alternative splicing. Different tissues show remarkably different frequencies of alternative splicing, with the brain accounting for approximately 18 percent of such events. (a) Define alternative splicing and speculate on the evolutionary strategy alternative splicing offers to organisms. (b) Why might some tissues engage in more alternative splicing than others?
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Alternative splicing is present in about 90% of human genes and can explain why our 20,325 genes can encode more than 1,000,000 proteins. Examine the image below of Gene Alpha. Gene Alpha Exon #1 Intron A Exon #2 Intron B Exon #3 1. (2 pts) To create a transcript, which portions of this DNA sequence would be REMOVED during splicing? (Please be specific - ie. Exon #1, Intron A, etc.) 2. (3 pts) Gene Alpha can encode 7 different proteins! Explain how alternative splicing can lead to this phenomenon and give at least 3 specific examples of the different proteins that could be produced from Gene Alpha.
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