although the three complement pathways are activated by different molecules, they converge on the same step called
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Although activation of the three different pathways of complement involves different components, the three pathways converge on a common enzymatic reaction referred to as complement fixation. Please provide a short answer to each of the following: a. Describe this reaction. b. Describe the enzyme responsible for this reaction in the alternative pathway. c. Identify three effector mechanisms of complement that are enabled by this common pathway.
Sri K.
Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because: Two of the three pathways for complement activation are initiated by constitutively produced recognition molecules that directly interact with microbial surfaces. When the complement cascade leads to the formation of a membrane-attack complex, the pathogen is killed. Several of the soluble products generated by complement activation promote the inflammatory response. Complement proteins bound to the pathogen promote uptake and destruction by phagocytic cells. The C3 convertase is only produced when complement activation is initiated by antibody binding to a pathogen.
The complement regulatory protein CD59 is known to prevent the terminal stages of the complement cascade. What happens in the terminal stages when the complement system is activated? C5 convertase is formed C4 and C2 are cleaved The membrane attack complex is formed C3 convertase is formed
Adi S.
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