An acidic pKa of 3 will make a functional group at physiological pH of 7.4 Group of answer choices C. equally ionized and unionized A. mainly ionized B. mainly unionized
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Step 1: Identify the pKa of the acidic functional group, which is given as 3. Show more…
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Madhur L.
All amino acids have two ionizable functional groups: an α-amino group (average pKₐ of 9.4) and an α-carboxylic acid group (average pKₐ of 2.2). Histidine also has an ionizable side chain (R group) with a pKₐ of about 6.0. One of the possible ionization states of histidine is shown in the image. At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups. The protonated form of the R group of histidine is shown in the structure. The ratio of the charged (protonated) form to the deprotonated form depends on the pKₐ of the R group and the pH of the solution. Select the pH values at which the charged form of the R group would predominate:
Adi S.
All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4) and an α-carboxylic acid group (average pKa of 2.2). Histidine also has an ionizable side chain (R group) with a pKa of about 6.0. One of the possible ionization states of histidine is shown in the image. At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups.
Supreeta N.
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