Analysis of neuroblastoma cell lines revealed that GTL2 DMR hypermethylation was associated with transcriptional repression of GTL2. These epigenetic findings are similar to those reported in Wilms' tumors in which H19 repression and DMR hypermethylation is associated with loss of imprinting (LOI, biallelic expression) of IGF2. However, a neuroblastoma cell line with hypermethylation of the GTL2 promoter and intergenic DMR did not show LOI of DLK1 and although treatment with a demethylating agent restored GTL2 expression and reduced DLK1 expression.
Added by Tina P.
Step 1
Step 1: The analysis of neuroblastoma cell lines revealed that GTL2 DMR hypermethylation was associated with transcriptional repression of GTL2. Show more…
Show all steps
Your feedback will help us improve your experience
Sri K and 68 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
You perform a karyotype on cells from a cancer sample and you see a normal chromosomal array (44 autosomes and 2 sex chromosomes). However, when you perform gene expression profiling, you see that gene expression in the cancerous tissue is different than in adjacent normal tissue. Select scenarios that are consistent with your observations. Check all that apply. A translocation has activated an oncogene in the cancer cells. Point mutations have changed the expression patterns of several transcription factors in the cancer cells. Epigenetic changes throughout the genome have changed the expression patterns of genes. A chromosomal inversion has inactivated a tumor suppressor. Chromothripsis has occurred.
Sri K.
Researches began a study of a cultured cell line. Their preliminary observations showed them that the cell line did not exhibit either density-dependent inhibition or anchorage dependence. What could they conclude right away? A. The cells originated in the nervous system B. The cells are unable to form spindle microtubules C. The cells have altered series of cell cycle phases D. The cells show characteristics of tumors
Benjamin D.
One difference between mitosis and meiosis is that mitosis produces genetically identical daughter cells while meiosis produces haploid cells. During anaphase, homologous chromosomes randomly separate and migrate to opposite poles, while sister chromatids separate and the daughter chromosomes migrate to opposite poles. Each pole of the cell inherits half of the chromosomes from the mother and half from the father. The exception to genetic variation is DNA replication.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD