And how are ketone bodies broken down to Acetyl CoA in skeletal muscle
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Discuss the role of ketone bodies that enter the muscle after being liberated from the liver during vigorous muscular work in controlling the activity of these sites.
Madhur L.
The primary fate of acetyl CoA under normal metabolic conditions is degradation in the citric acid cycle to yield $\mathrm{CO}_{2}$. When the body is stressed by prolonged starvation, however, acetyl CoA is converted into compounds called ketone bodies, which can be used by the brain as a temporary fuel. Fill in the missing information indicated by the four question marks in the following biochemical pathway for the synthesis of ketone bodies from acetyl CoA: (EQUATION CAN'T COPY)
Describe the processes by which fatty acids are transported in the blood, activated and transported into the matrix of the mitochondria for breakdown to obtain energy. (Specifically, determine the role of carnitine palmitoyl transferase in the oxidation of fatty acids.) Explain the processes by which fatty acids are released from triacylglycerol stored in adipose tissue. Outline the β-oxidation pathway by which fatty acids are metabolized to acetyl-CoA and explain how this leads to the production of large quantities of ATP. Identify the three compounds termed “ketone bodies” and describe the reactions by which they are formed in liver mitochondria.
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