The amino acid residue that would LEAST likely be buried in the interior of a water-soluble globular protein is: lysine. tyrosine phenylalanine. methionine isoleucine What would be the overall charge of the peptide Asp-Ala-Arg-His at pH 4? 3 0 2 –1 1 Citric acid is an important intermediate in glucose metabolism and is synthesized in the mitochondrial matrix. The pKa values for each of the three carboxylic groups of the citric acid are 3.1, 4.8, and 6.4. What is the charge on a citrate molecule formed in the mitochondrial matrix where the pH is 5.8? –3 +2 –2 +1 +3 Which amino acids would be most soluble in a nonpolar solvent such as toluene? threonine Leucine histidine glutamine glycine Which statements about the polypeptide Ser-Tyr-Gly-Phe-Met-Gly are CORRECT? Select all that apply. Serine is the N-terminal residue. Glycine is the C-terminal residue. Glycine is the N-terminal residue. Methionine is the N-terminal residue. Serine is the C-terminal residue
Added by Whitney H.
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Step 1: The amino acid residue that would least likely be buried in the interior of a water-soluble globular protein is lysine, as it is a very polar amino acid with a plus charge, making it more likely to be found on the exterior interacting with water molecules. Show more…
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The complete hydrolysis of an unknown peptide revealed the presence of the following amino acids: glutamic acid, 2 valine, glycine, 2 lysine, tyrosine, threonine and phenylalanine. The first amino acid to be detected by an Edman degradation of the peptide was glutamic acid. The only amino acid detected after digestion with carboxypeptidase was threonine. Treatment of the peptide with trypsin and chymotrypsin gave three fragments in each case: T1, T2, T3 and C1, C2, C3 respectively. None of the trypsin fragments was the same as a chymotrypsin fragment. C2 and T2 were dipeptides C1 and T1 were tripeptides and C3 and T3 were tetrapeptides. The N-terminal residue of T3 was shown to be phenylalanine and the C-terminus was threonine. The N-terminal end of C1 was glycine and the C-terminus was the same as T3. T1 was found to contain tyrosine, lysine and glutamic acid while C2 contained tyrosine and glutamic acid. The N-terminal end of C3 was lysine. At basic pH the C3 fragment migrated with a net charge of +2. Construct a sequence for the unknown peptide. Discuss your rationale.
Josee P.
1. Two amino acids of the standard 20 contain hydroxyl-groups. They are: methionine and cysteine. cysteine and serine. cysteine and threonine. methionine and serine. threonine and serine. 2. Three of the 20 amino acids that are incorporated into proteins are aromatic. They are: tyrosine, phenylalanine, and tryptophan. valine, leucine, and isoleucine. tryptophan, phenylalanine, and proline. tyrosine, phenylalanine, and proline. arginine, lysine, and histidine. 3. There are several amino acid side chains which are always charged at physiological pH. These are: Glu, Asp, Lys, and His. Gln, Asn, Glu, and Asp. Glu, Lys, Asp, His, and Arg. Glu, Asp, Lys, and Arg. none of the above. 4. Which one of the following sequences of five amino acids would most likely be located in the interior of a globular soluble protein? Val-Ala-Val-Glu-Val Met-Cys-Pro-His-Tyr Met-Phe-Pro-Ile-Leu Tyr-Phe-Glu-Asn-Leu
Adi S.
Determine the minimum energy cost, in terms of ATP equivalents expended, for the biosynthesis of the $\beta$ -globin chain of hemoglobin (146 residues), starting from a pool including all necessary amino acids, ATP, and GTP. Compare your answer with the direct energy cost of the biosynthesis of a linear glycogen chain of 146 glucose residues in $(a 1 \rightarrow 4)$ linkage, starting from a pool including glucose, UTP, and ATP (Chapter 15 ). From your data, what is the extra energy cost of making a protein, in which all the residues are ordered in a specific sequence, compared with the cost of making a polysaccharide containing the same number of residues but lacking the informational content of the protein? In addition to the direct energy cost for the synthesis of a protein, there are indirect energy costs - those required for the cell to make the necessary enzymes for protein synthesis. Compare the magnitude of the indirect costs to a eukaryotic cell of the biosynthesis of linear $(\alpha 1 \rightarrow 4)$ glycogen chains and the biosynthesis of polypeptides, in terms of the enzymatic machinery involved.
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