Antimicrobial Drug Mode of action Penicillin Affects...

Antimicrobial Drug Mode of action Penicillin Affects peptidoglycan to cause cell wall damage and lysis Chloramphenicol Inhibits protein synthesis by binding to 70S ribosomes Amphotericin B Binds to ergosterol to affect cell membrane Quinines Causes buildup of toxic free radicals in parasite's cells Oseltamivir Prevents viral budding Refer to the table given above to answer the following: A) Which of the drug(s) given in the table above could be used to treat yeast infection with selective toxicity? B) Explain why your choice of antimicrobial(s) would be selectively toxic. C) Explain why you eliminated all the other choices of antimicrobials

Transcript

00:01 Hello, we will be talking about various aspects of treatment which can be used for yeast infections.

00:16 So for the first part, if we need to see the drugs that can be used for this treatment, then it includes penicillin and the other one is amphotarrison b.

00:37 For the second part, first we will talk about selective toxicity.

00:49 So selective toxicity is basically the ability that a medicine has with the help of which it is able to target the locals that are specific to some microorganism which help it to cause a disease or to cause a infection.

01:22 So if a medicine is able to target this particular local, then it is called as selective toxicity of that medicine.

01:30 And this local it is specific why because it renders the organism with a high endurance, thus increasing its rate of survival.

01:45 So if we consider the drugs for yeast infection, then the drug penicillus, then the drug penicillus.

01:52 It has a selective toxicity why because it affects peptidoglycan now this peptidoglycan it is present in the cell wall because of which the cell wall of the organism it is bound to rupture so for this reason we can use penicillin against the yeast and also the human cell it does not have any peptidoglycan.

02:29 So because of this reason the penicillin is not going to affect the human cell.

02:34 It is going to be selectively toxic only for the yeast or the fungal cells.

02:40 Another drug that we talked about in first part that is the amphotericin b...

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