Apoptosis triggered by X-ray induced DNA damage activates a pathway which results in: a. Binding of Mdm2 and p53. b. Ubiquitination and degradation of p53. c. Downregulation of the BH-3 only proteins PUMA and NOXA. d. Production of p21 which binds and inhibits G1/S-Cdk.
Added by James S.
Step 1
Step 1: Apoptosis triggered by X-ray induced DNA damage activates a pathway. Show more…
Show all steps
Your feedback will help us improve your experience
Adi S and 61 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Mammalian cells damaged by radiation usually stop dividing and arrest at a G1 checkpoint. The events that mediate this process occur in the following order: A) DNA damage, production of p21, inhibition of cyclin-Cdk, accumulation and activation of p53 B) DNA damage, accumulation and activation of p53, production of p21, inhibition of cyclin-Cdk complexes C) Inhibition of cyclin-Cdk complexes, accumulation and activation of p53, DNA damage, production of p21 D) Accumulation and activation of p53, DNA damage, production of p21, inhibition of cyclin-Cdk complexes E) None of the above
Md.Daniyal A.
A cell has been subjected to X-ray irradiation, causing a significant number of mutations in the genome. Which of the following would you NOT expect to occur as a result? A. Activation of the protein kinase ATR B. Activation of the protein kinase Chk1 C. Inactivation of the protein phosphatase Cdc25 D. Binding of p53 to Mdm2 E. Stabilization of p53
Adi S.
p53 can trigger apoptosis if certain cell cycle events fail. How does this regulatory outcome benefit a multicellular organism? a. The apoptosis helps in controlling the consumption of energy by the extra cells. b. The apoptosis inhibits the production of faulty proteins, which could be produced due to the DNA damage. c. The process of apoptosis stops the invasion of viruses in the other cells. d. The cells are killed due to the production of reactive oxygen species produced, which could harm the organism.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD