At a cellular level in this example explain what occurs if the APC gain is mutated
Added by Connie G.
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Step 1: State the normal APC function — APC protein is a component of the β-catenin destruction complex (with Axin, GSK3β and CK1), promotes phosphorylation and ubiquitin-mediated proteasomal degradation of β-catenin, and also contributes to microtubule dynamics Show more…
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(A) Overactivity Mutation (Gain of Function) A single mutation event creates an oncogene in a normal cell. This activating mutation enables the oncogene to promote cell transformation. (B) Underactivity Mutation (Loss of Function) Mutation event inactivates tumor suppressor gene. No effect of mutation in one gene copy. Second mutation event inactivates second gene copy. Two inactivating mutations functionally eliminate the tumor suppressor gene, promoting cell transformation. cells en route to cancer
Sri K.
25. Watch the video clip. At the cellular level in this example, explain what occurs if the APC gene is mutated. 26. Normally, proto-oncogenes stimulate the cell cycle. What do mutated proto-oncogenes (i.e., oncogenes) cause? 27. Normally, tumor suppressor genes inhibit the cell cycle. What do mutated tumor suppressor genes cause?
what happens if mutation causes the loss of checkpoint...
Adi S.
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