Beriberi is a nutritional deficiency disease resulting from inadequate thiamine in the diet. Individuals lacking thiamine accumulate two metabolites as a consequence of eating sugar – what are they? Please explain the reasoning behind the answer.
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It acts as a cofactor for several enzymes involved in carbohydrate metabolism, including transketolase, pyruvate dehydrogenase, and α-ketoglutarate dehydrogenase. When there is a deficiency of thiamine, these enzymes cannot function properly, leading to the Show more…
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1. Beriberi is the condition that results from a lack of thiamine, the precursor of TPP. What 2 metabolites would accumulate in a person suffering from Beriberi after eating glucose?
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Thiamine (vitamin B1) deficiency diseases have a lower prevalence now than in the past. However, they are seen as beriberi in some developing regions and in regions of crisis, and as Wernicke–Korsakoff syndrome in some alcoholics. One type of beriberi causes neurological symptoms such as weakness, fatigue, and loss of sensation. What is a possible explanation for these symptoms?
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