Bone marrow aspirate dry tap bone marrow biopsy...

Name: bone marrow aspirate dry tap bone marrow biopsy hypercellularity with increased myeloid cells increased megakaryocytes dysgranulopoiesis dysmegakaryopoiesis and fibrosis jak2 v617f mutation 96395
Uploaded: 2023-07-18T14:50:33-08:00
Duration: 3 min 30 s
Channel: Madhur L
Description: bone marrow aspirate dry tap bone marrow biopsy hypercellularity with increased myeloid cells increased megakaryocytes dysgranulopoiesis dysmegakaryopoiesis and fibrosis jak2 v617f mutation 96395

Bone marrow aspirate: dry tap Bone marrow biopsy: hypercellularity with increased myeloid cells, increased megakaryocytes, dysgranulopoiesis, dysmegakaryopoiesis, and fibrosis JAK2 V617F mutation present Based on all the data provided, what condition is most likely? O AML O ALL O MM O primary myelofibrosis(PMF)

A bone marrow was performed on Khadeejah. The marrow showed a cellularity of about 75%. There was myeloid hyperplasia with 9% blasts, 26% promyelocytes, 18% myelocytes, 6% metamyelocytes, 4% bands, and 37% eosinophils. The ratio of myeloid-to-erythroid precursors (M:E) was 12:1. The myelocytes were hypogranular, and some had two nuclei. The erythroid precursors showed megaloblastoid changes. Megakaryocytes were adequate in number but showed abnormal forms with nuclear separation and single nucleated forms. 7. Which of the hematopoietic cell lines exhibit dyshematopoiesis in the bone marrow? 8. How would you classify the bone marrow cellularity? Why? 9. Identify at least two features of the bone marrow that are compatible with the diagnosis. 10. What chemistry tests would be helpful to rule out megaloblastic anemia? 11. How would you treat this particular patient?

Madhur L.

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