00:01
Okay, i want to answer this question, let's talk about the neuromuscular junction.
00:04
Remember that if this is your neuron, for example, okay, and this is the axon terminal, this neuron, let's suppose it is going to be a motor neuron.
00:16
This motor neuron is going to have many vesicles containing acetylcholine.
00:21
And here we're going to have the sarcolemic, it means the cell membrane of your skeletal muscle.
00:26
So once an action potential is fired from this motor neuron, it is going to depolarize a membrane and it is going to open voltage -gated calcium channels.
00:39
Okay, and it is going to allow the movement of calcium inside of this axon terminal.
00:43
And this calcium is going to be helpful in order to allow extraceotosis of these vesicles.
00:49
And you're going to have the acetylcholine that is going to be released to this space here.
00:55
Okay? after this acetylcholine has been released here on your circle of my, you're going to have nicotinic receptors, okay, that are normally going to be closed.
01:09
But once acetylcholine binds to this, then this part here are ion channels.
01:16
Okay, these nicotine receptors are attached to ion channels...