Botulism is a potentially fatal foodborne disease caused by the bacterium Clostridium botulinum. C. botulinum produces different toxins, several of which are proteases that cleave neuronal SNARE proteins. What normal process is blocked by cleavage and inhibition of SNARE proteins? Choose one: A. fusion of vesicles with target membranes B. docking of vesicles to target membranes C. entry of proteins with ER signal sequences into the ER lumen D. budding of vesicles from the endoplasmic reticulum
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Step 1: SNARE proteins are short proteins that are bound to the surface of vesicles and target membranes. Show more…
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In botulism, a type of food poisoning, the poison produced by bacteria in the spoiled food prevents the person's synaptic vesicles from fusing with the neuron's membrane. You would expect that this effect would a. cause excessive destruction of neurotransmitter in the synaptic cleft. b. destroy myelin. c. prevent the message of the presynaptic cell from reaching the postsynaptic cell. d. cause neurotransmitters to clog the synaptic cleft.
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