Ciliobrevins are specific small molecule inhibitors of the AAA+ domain of cytoplasmic dynein. For each of the following processes, would ciliobrevins disrupt the process or not? Movement of vesicles toward the minus ends of microtubules Movement of vesicle-packaged cargo from the Golgi to the ER or cell periphery Contraction of smooth muscle cells Swimming of human sperm Movement of materials along cilia and flagella would be disrupted would not be disrupted
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- Cytoplasmic dynein is a motor protein that moves along microtubules towards the minus end, which is typically oriented towards the cell center. It is involved in various cellular processes, including vesicle transport, organelle positioning, and movement of Show more…
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A mitotic dynein (a motor protein that binds astral microtubules) that is localized exclusively to the cell membrane. a. The mitotic spindle would be unchanged as this is the normal localization of dynein. b. The poles would be drawn further apart as the dynein would pull the spindle poles to the membrane. c. The poles would be closer, as the decreased motor function on astral microtubules would be weaker than the forces pulling poles together. d. The cell membrane would lose permeability as the dynein motors would induce microtubule polymerization through the membrane.
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