CD45 is a O serine kinase that activates phospholipase C-$\gamma$ (PLC-$\gamma$) O serine kinase that cross-links Blk, Fyn and Lyn O tyrosine phosphatase that activates receptor-associated kinases O tyrosine kinase that binds to phosphorylated Ig$\beta$ O none of the answers are correct
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CD45 is a well-known transmembrane glycoprotein expressed on hematopoietic cells. It is a protein tyrosine phosphatase. Let's evaluate each option: * **O serine kinase that activates phospholipase C-$\gamma$ (PLC-$\gamma$)**: CD45 is a tyrosine phosphatase, Show more…
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Protein tyrosine kinase activity following T-cell stimulation: Select one: a. Phosphorylates and thereby activates phospholipase C̱1 b. Is an inherent property of the T-cell receptor ̱ and ̲ chains c. Is an inherent property of CD3 d. Is decreased e. Is unrelated to phosphorylation of the CD3-associated ̰ chains
Sri K.
Signaling. Protein tyrosine phosphatases, such as the molecule CD45 expressed in both B cells and T cells, play important roles in activating such protein tyrosine kinases as Fyn and Lck, which are quite similar to Src. Suggest a mechanism for the activation of such protein kinases by the removal of a phosphoryl group from a phosphotyrosine residue.
Which of the following signaling events is NOT engaged downstream of phospholipase C (PLC)-gamma activation? IkappaB degradation and resulting translocation of NFkappaB into the nucleus PIP3 generation at the plasma membrane which recruits and activates Akt, leading to cytoskeletal remodeling Heterodimerization of the subunits c-Fos and c-Jun to form the transcription factor AP Calcium ion (Ca2+) release from the endoplasmic reticulum (ER) Recruitment of protein kinase C (PKC)-theta to the plasma membrane
Bryan V.
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