Cell Treatment Effect on function of signal transduction pathway Pathway 1Pathway 2No treatmentNo effect; pathway fully functionalNo effect; pathway fully functionalIncubation with protease enzymeComplete loss of functionComplete loss of functionIncubation with glycosidase enzymeNo effect; pathway fully functionalComplete loss of function Which hypothesis is supported by these results? Receptors for signal transduction pathways 1 and 2 bind the same ligands. Pathway 1 involves a ligand that recognizes a glycoprotein receptor, and pathway 2 involves a ligand that recognizes a nonglycosylated protein receptor. Receptors for signal transduction pathways 1 and 2 bind ligands that recognize nonglycosylated proteins. Pathway 1 involves a ligand that recognizes a nonglycosylated protein receptor, and pathway 2 involves a ligand that recognizes a glycoprotein receptor. Receptors for signal transduction pathways 1 and 2 bind ligands that recognize glycoproteins.
Added by Francisco Jose Q.
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- No treatment shows that both pathways are fully functional. - Incubation with protease enzyme results in a complete loss of function for both pathways. - Incubation with glycosidase enzyme shows no effect on pathway 1 but a complete loss of function for pathway Show more…
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Adi S.
4. Describe characteristics that are unique to the signaling pathway. a. Are second messengers involved, yes or no? If so, name the second messengers? b. Are scaffold proteins involved, yes or no? If so, name the scaffold proteins? c. Are protein kinases involved, yes or no? If so, what is its function? d. Is a G-protein involved, yes or no? If so, name the G-protein involved. 5. Signal-transduction pathways occasionally fail, leading to diseases such as diabetes, heart disease, autoimmunity, cancer, and sometimes mental disorders. Explain the steps in the abnormal signaling pathway that led to your selected disease or disorder. Be sure to discuss the ligand that binds, the receptor protein, relay proteins involved, scaffold proteins, and second messengers. Are there downstream receptors or relay proteins that are non-functioning, yes or no?
Sri K.
The image below is a made-up signaling pathway. When the signaling molecule binds to the receptor, the enzymes ABC and DEF (light green, nine-sided figures) are activated. ATK, RAS, and LMN are different proteins in the signaling pathway. Use the pathway to answer the following questions: 1. What kind of receptor is shown on the plasma membrane? How can you tell? (1 pt) 2. Using what you know about phosphorylation, what kind of enzymes are ABC and DEF? Why? Hint--they are different kinds of enzymes. (1 pt) 3. The fact that the same receptor can activate multiple different response pathways (Cell Response 1 and 2 in the image) is an example of what kind of cell signaling regulation (e.g. amplification, efficiency, etc.)?
Bryan V.
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