Chemokine receptors are the co-receptor for HIV, what is significant about the delta 32 mutation? Answers: A - D A The mutation increases the glycosylation of the virus B The deletion prevents attachment C The delta 32 mutation enhances the cytokine storm D It enhances the attachment
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Step 1: The delta 32 mutation is a deletion in the CCR5 gene, which codes for a chemokine receptor. Show more…
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Choose all that apply and give an explanation - Individuals homozygous for the CCR5 Delta 32 mutation have resistance against M-tropic HIV strains but are more susceptible to several forms of viral-caused encephalitis. Which statements below are true? a) The missing amino acids prevent the HIV from recognizing and attacking the white blood cell, but then cause the cell to fail to interact with the virus as it normally would. b) This is an example of trade-offs that affect the Coevolutionary Arms Race. c) This beneficial trait is due to an early-acting mutation and occurs in higher than expected frequency in the population due to selection pressure caused by the recent spread of M-tropic strain HIV. d) None of these statements are true.
Shaiju T.
Why is a mutant CCR5 receptor often associated with resistance to HIV infection? A. The immune system in people with the mutated CCR5 receptor is inadvertently activated to recognize HIV particles, conferring resistance to infection. B. The mutant receptor binds to and inactivates circulating HIV particles. C. HIV interacts with normal CCR5 surface receptors and use them to gain entry to the cell's interior. D. The CCR5 receptor causes a signal transduction effect which inhibits protease activity required for HIV particle assembly. E. The gene for the mutant CCR5 receptor is on the chromosome next to the gene for an enzyme that digests HIV's gp120 surface protein.
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How does the CCR5 mutation protect an individual from HIV? A. This mutation has no effect on host resistance B. It kills the Plasmodium bacteria before it enters the immune cells C. It can prevent HIV attachment to immune system cells by eliminating an important receptor D. It causes the red blood cells to burst E. It prevents replication by the virus
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