1. Chromatin can be modified to affect gene expression in...

1. Chromatin can be modified to affect gene expression in various ways. Explain each of these different ways that chromatin structure can be altered and also explain how this effects gene expression. Histone modification: Nucleosome remodeling: Histone Variants: 2. The acetylation of histone tails can result in the ____ of gene expression, and the de-acetylation of histones can result in the ____ of gene expression. 3. What is a nucleosome and what four histones comprise them?

Transcript

00:01 The gene expression of a chromosome can be modified in several ways.

00:09 So there are several modification by which you can increase or decrease the expression levels.

00:18 So what are the ways and effects on their expression of the factors? so the given options or not options the given concepts are histone modification.

00:38 Then you have chromosomes, nucleosome remodeling.

00:46 Now histone modification or nucleosome remodeling.

00:50 So these are the terms which are interlinked.

00:54 So you cannot separately define them.

00:56 So i'm going to explain it with all together.

01:00 Then going for a different explanation and the histone variance so basically what are histones first of all let's see so histones are basic proteins they are basic in nature they are basic proteins and due to which they are getting attracted to the dna so these proteins are the fundamental structure or you can also say the basic structure that is involved in the holding of dna so which is involved in the formation of nucleosome model okay so see i have taken here a nucleosome model so what you can see nucleus of model you can see the various types of histone proteins so what are the histone variants are there are how many types of histone proteins so basically there are four types of histone proteins that is h2a h2 b h3 and h4 so all of them are into two copies that four so you can see in this model see you can see h2 a a h2 b h2 b h3 and h4 so this all together is called as histone model or the histone proteins and when the dna is wrapped around this stone proteins we call it as a one nucleosome model so there is approximately 147 base pairs of dna which is being wrapped around these stone molecules which forms a nuclear model so what are the effect it is going to affect on the chromatin compaction so there is a chromatin compaction due to this stone arrangement or nucleus of model and also it will affect the accessibility of transcription factor to the dna so eventually what will happen when there is a nucleus of model formation the transcription level or the g expression you can say will decrease because now the dna is going into the more compact form and eventually it is going to form the chromosome structure and what does this nucleus of remodeling says? so, nucleosome remodeling involves the various histone dna interactions like disrupting, assembling or moving of the nucleus of model, which is done during the gene expression...

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