00:02
All right, this question is asking you about spliceosomes.
00:06
Spliceosomes are involved in the cell, specifically in pre -mrna processing.
00:16
And what they do is they take a mri molecule, and this mrna molecule will have different sections.
00:25
It will have sections called exons and sections called introns.
00:39
I should make that singular.
00:42
So the reason this is important is that before an rna is sent to be translated, these introns get cut out by splicisomes.
00:53
And so what you end up with is just the exons part, and that will be the actual mrna that gets translated into a protein.
01:03
Well, it says that people's leukemia often have nonsense mutations in their spliceosome.
01:08
And i don't think this is really key to understand the question, but a nonsense mutation takes a regular codon that produces an amino acid and turns it into a stop codon.
01:23
And so for this reason, the nonsense mutation in someone with leukemia is going to cause spliceosomes not to work right.
01:32
And so when these spliceosomes don't work right, then they may not cut out these introns right.
01:40
And so these introns may still be present.
01:45
Now, the reason that that is such a problem is that if the intron is still present, then the mrna produced is going to look a lot different than without the introns...