compared to a typical cell not exposed to ligand, what will happen to gene transcription if the signaling molecule (ligand) is absent, but the Ras protein is always bound to GTP and why?
Added by Jonathan W.
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Ras is a small GTPase that acts as a molecular switch in various signaling pathways, particularly those involved in cell growth and differentiation. When Ras is bound to GTP, it is in an active state and can propagate signals downstream. Show more…
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What will happen to gene transcription if the signaling molecule (ligand) is absent, but the Ras protein is always bound to GTP and why? a. Gene transcription would decrease because Ras-GTP is the inactive form of the signal transduction protein. b. Gene transcription would not change because the receptor must be activated for signal transduction to occur. c. Gene transcription would increase because the Ras-GTP is the active form of signal transduction protein for cell division. d. Gene transcription would not change because the signal is needed to activate signal transduction for cell division.
Madhur L.
The Ras protein functions as a molecular switch that is set to its "on" state by other proteins that cause it to release its bound GDP and bind GTP. A GTPase-activating protein helps reset the switch to the "off" state by inducing Ras to hydrolyze its bound GTP to GDP much more rapidly than it would without this encouragement. Thus, Ras works like a light switch that one person turns on and another turns off. You are studying a mutant cell that lacks the GTPase-activating protein. What abnormalities would you expect to find in the way in which Ras activity responds to extracellular signals?
The Ras protein functions as a molecular switch that is set to its "on" state by other proteins that cause it to expel its bound GDP and bind GTP. A GTPase-activating protein helps reset the switch to the "off" state by inducing Ras to hydrolyze its bound GTP to GDP much more rapidly than it would without this encouragement. Thus, Ras works like a light switch that one person turns on and another turns off. You are given a mutant cell that lacks the GTPase-activating protein. What abnormalities would you expect to find in the way in which Ras activity responds to extracellular signals?
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