Complete each sentence about type IV hypersensitivities and then arrange the sentences in a logical sequence. Not all words are used.
Compared to type III hypersensitivities, Type IV reactions primarily involve T cell activity.
Host rejection of grafted tissue is due to B-mediated reactions, while GVHD occurs when cells in the grafted tissue attack host cells.
Autografts, or tissue used from one's own body, offer the lowest risk of graft rejection; these are followed by isografts (identical twin donor); allografts, which are the most common source of grafts today; and xenografts, which are experimental as genetic engineering works to reduce their antigenicity in humans.
The most common delayed allergic reaction, however, is contact dermatitis, which occurs after exposure to antigens in plant resins, drugs or personal articles, and involves the production of inflammatory cytokines that cause blistering.
One example occurs during the tuberculin skin test in people sensitized by tuberculosis infection.
Type IV dysfunction is known as delayed hypersensitivity because symptoms arise one to several days following secondary antigen exposure.