Question

Consider the following synapse: (Presynaptic Neuron A) O------< O------< (Postsynaptic Neuron B) Assume the following: Neuron A forms a synapse with Neuron B. Neuron A is a Dogium neuron. Dogium is a (made-up) neurotransmitter that binds to the ionotropic receptors Dog1 and Dog2. Neuron B contains both the Dog1 and Dog2 receptors in its postsynaptic membrane. Activation of the Dog1 receptor opens Na+ channels, while activation of the Dog2 receptor opens Cl- channels. At baseline (without input from neuron A), neuron B has a medium action potential firing rate. If neuron A fires at a low rate, neuron B's firing rate increases. As neuron A fires at a high rate, neuron B's firing rate decreases. 6.) What can you infer about the properties of the Dog1 and Dog2 receptors that would explain how neuron B responds to different rates of input from neuron A? (Hint: Think about neurotransmitter concentrations and binding affinities?)

          Consider the following synapse:
(Presynaptic Neuron A) O------< O------< (Postsynaptic Neuron B)

Assume the following:
Neuron A forms a synapse with Neuron B. Neuron A is a Dogium neuron. Dogium is a (made-up) neurotransmitter that binds to the ionotropic receptors Dog1 and Dog2. Neuron B contains both the Dog1 and Dog2 receptors in its postsynaptic membrane. Activation of the Dog1 receptor opens Na+ channels, while activation of the Dog2 receptor opens Cl- channels.

At baseline (without input from neuron A), neuron B has a medium action potential firing rate. If neuron A fires at a low rate, neuron B's firing rate increases. As neuron A fires at a high rate, neuron B's firing rate decreases.

6.) What can you infer about the properties of the Dog1 and Dog2 receptors that would explain how neuron B responds to different rates of input from neuron A? (Hint: Think about neurotransmitter concentrations and binding affinities?)

Added by Vicente M.

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