Question

38. Considering the proposed translated polypeptide (drawn above) with the labeled start and stop sequences, if the first start sequence was an ER signal sequence, we would expect that this polypeptide would end up as a transmembrane protein that crosses the phospholipids bilayer _ times and is oriented in the membrane with its _ a) four; NH2 and COOH terminal facing the ER lumen b) four NH2 and COOH terminal facing the cytosol c) six; NH2 terminal facing the ER lumen and its COOH terminal facing the cytosol d) seven; NH2 terminal facing the ER lumen and its COOH terminal facing the cytosol e) seven; NH2 terminal facing the cytosol and its COOH terminal facing the ER lumen 39. Structurally speaking, the cis network of the golgi typically faces the _, while the trans network faces the _ a) mitochondria; nucleus b) nucleus; rough ER c) rough ER; mitochondria d) plasma membrane; rough ER e) nucleus; plasma membrane 40. In a water environment, "detergents" tend to form "micelles" instead of bilayers primarily because detergents _ a) are non-polar lipids and bilayers can only be formed by dipolar lipids b) completely dissociate into ions during micelle formation whereas bilayers do not c) are purely lipid in nature and only lipid-protein complexes can form bilayers d) have only 1 non-polar tail while membrane lipids that form bilayers have 2 non-polar tails e) lack the phosphate groups necessary for bilayer formation 41.Two types are of glycolipids present in the glycocalyx of animal cells are _ and ___ a. inositol; sphingomyelin b. sphingomyelin; cerebrosides c. cerebrosides; gangliosides d. gangliosides; inositol e. glycophorin; ankyrin 42. The MAJOR role of the protein clathrin during endocytosis is to _ a. decide which chemicals the cell needs to engulf b. provide ATPase activity during endocytosis c. help form a basket-like network on the cytosolic side of the plasma membrane d. help dissolve away the extra phospholipids during budding e. act as a recognition protein for the binding of SNAREs 43. Which of the following membrane lipids have the highest rate/frequency of "flip flop" movement? a) sphingomyelin b) glucocerebroside c) phosphatidylcholine d) cholesterol e) none of these can ever do flip flop movement in the membrane 44. A major difference between the way a protein crosses mitochondrial membranes compared to the way a protein crosses the nuclear envelope is that a protein that crosses the mitochondrial membrane _. a) always keep their signal sequence after they cross b) must unfold to be translocated c) always cross one membrane at a time d) enters the mitochondrial matrix in the form of membrane vesicles e. uses mitochondrial ribosomes to finish their translation once across 45. Which of the following can be used to remove integral proteins from their membrane? a) high O2 pressure b) sodium dodecyl sulfate c) pH changes d) high salt concentration e) mercaptoethanol 46. If a newly synthesized protein had its ER signal sequence at the NH2 terminal and a single stop transfer sequence 1/3 of the way down the length of the polypeptide chain, then we could expect that it would __ a) end us as a peripheral protein on the cytosolic face of the ER b) not be able to be completely translated by the ribosome c) enter the lumen of the ER but would not migrate on to the golgi d) become a transmembrane protein in some structure of the endomembrane system e) have started its translation at the rough ER but the stop sequence would have freed the ribosome from the ER membrane

38. Considering the proposed translated polypeptide (drawn above) with the labeled start and stop sequences, if the first start sequence was an ER signal sequence, we would expect that this polypeptide would end up as a transmembrane protein that crosses the phospholipids bilayer _ times and is oriented in the membrane with its _
a) four; NH2 and COOH terminal facing the ER lumen b) four NH2 and COOH terminal facing the cytosol
c) six; NH2 terminal facing the ER lumen and its COOH terminal facing the cytosol
d) seven; NH2 terminal facing the ER lumen and its COOH terminal facing the cytosol
e) seven; NH2 terminal facing the cytosol and its COOH terminal facing the ER lumen
39. Structurally speaking, the cis network of the golgi typically faces the _, while the trans network faces the _
a) mitochondria; nucleus b) nucleus; rough ER
c) rough ER; mitochondria d) plasma membrane; rough ER e) nucleus; plasma membrane
40. In a water environment, "detergents" tend to form "micelles" instead of bilayers primarily because detergents ___
a) are non-polar lipids and bilayers can only be formed by dipolar lipids
b) completely dissociate into ions during micelle formation whereas bilayers do not
c) are purely lipid in nature and only lipid-protein complexes can form bilayers
d) have only 1 non-polar tail while membrane lipids that form bilayers have 2 non-polar tails
e) lack the phosphate groups necessary for bilayer formation
41.Two types are of glycolipids present in the glycocalyx of animal cells are ___ and ___
a. inositol; sphingomyelin b. sphingomyelin; cerebrosides
c. cerebrosides; gangliosides d. gangliosides; inositol e. glycophorin; ankyrin
42. The MAJOR role of the protein clathrin during endocytosis is to _
a. decide which chemicals the cell needs to engulf b. provide ATPase activity during endocytosis
c. help form a basket-like network on the cytosolic side of the plasma membrane
d. help dissolve away the extra phospholipids during budding
e. act as a recognition protein for the binding of SNAREs
43. Which of the following membrane lipids have the highest rate/frequency of "flip flop" movement?
a) sphingomyelin b) glucocerebroside c) phosphatidylcholine d) cholesterol
e) none of these can ever do flip flop movement in the membrane
44. A major difference between the way a protein crosses mitochondrial membranes compared to the way a protein crosses the nuclear envelope is that a protein that crosses the mitochondrial membrane _.
a) always keep their signal sequence after they cross b) must unfold to be translocated
c) always cross one membrane at a time d) enters the mitochondrial matrix in the form of membrane vesicles
e. uses mitochondrial ribosomes to finish their translation once across
45. Which of the following can be used to remove integral proteins from their membrane?
a) high O2 pressure b) sodium dodecyl sulfate c) pH changes d) high salt concentration e) mercaptoethanol
46. If a newly synthesized protein had its ER signal sequence at the NH2 terminal and a single stop transfer sequence 1/3 of the way down the length of the polypeptide chain, then we could expect that it would __
a) end us as a peripheral protein on the cytosolic face of the ER
b) not be able to be completely translated by the ribosome
c) enter the lumen of the ER but would not migrate on to the golgi
d) become a transmembrane protein in some structure of the endomembrane system
e) have started its translation at the rough ER but the stop sequence would have freed the ribosome from the ER membrane

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