correct the sentence: in DSC experiments, if you found that molar enthalpy( delta Hm,cal) is larger than the delta Hm,vh it is likely that protein undergoes aggregation during the unfolding process
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A protein binds to a ligand with a ka of 2.9 x 10^5 M^-1s^-1 and a kd of 1.8 x 10^-2 s^-1. What is the molar concentration of ligand when Y is 0.75? 1.9 x 10^-7 6.2 x 10^-8 insufficient information to solve 4.8 x 10^7 Which of the following is CORRECT regarding protein misfolding and aggregation? Protein misfolding occurs only following accumulation of folding intermediates; it never results from misfolding of an already correctly folded protein. The propensity of proteins to aggregate in cells decreases following increased expression of cellular proteins. The formation of ordered aggregates via amyloidogenesis (of fibrillization) proceeds with an overall decrease in protein secondary structure. The specific activity, or reactivity, of misfolded proteins, expressed as the number of reactive sites per mg of total protein, decreases with the extent of fibrillization.
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Aggregation is an intrinsic property of proteins. Please use Gibbs free energy to explain how protein aggregation is thermodynamically favorable (considering the contributions of enthalpy and entropy from the changes of the protein and environment).
Adi S.
At body temperature, proteins have a very well-defined structure. As the temperature increases, proteins denature- changing shape and becoming non-functional. From this description what can you conclude about the sign for the enthalpy and entropy changes during denaturing? ΔH > 0 and ΔS > 0 ΔH > 0 and ΔS < 0 ΔH < 0 and ΔS > 0 ΔH < 0 and ΔS < 0 There is insufficient information to reach any conclusion.
Dinesh S.
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