Question 11 8 pts The graphs below show the response of a cell expressing WT receptors and one expressing mutant Nav1.7 (sodium) receptors (F1449V). A Wild-type B F1449V 60 155 pA 60 130pA 65pA 40 40 60pA 20 20 0 V (mV) 0 -20 V (mV) -20 -55 pA 50-65 pA -40 -40 50 pA -60 -60 -80 -80 0 20 40 60 80 100 0 20 40 60 80 100 Time (ms) Time (ms) -For figures A and B: What do the numbers (in pA) tell you about the experimental setup? -What difference do these figures highlight between the two cells? -Is this a gain-of-function or loss-of-function mutation?
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In this case, it represents the current generated by the sodium channels in the cell expressing either wild-type (WT) or mutant Nav1.7 receptors. Show more…
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