Describe three major feedback mechanisms that help to regulate the overall rate of de novo purine nucleotide synthesis and the relative rates of formation of the two end products, adenylate and guanylate.
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The first major feedback mechanism is the inhibition of the enzyme PRPP amidotransferase by the end products, AMP and GMP. When the levels of AMP and GMP are high, they bind to the enzyme and inhibit its activity, thus reducing the rate of de novo purine Show more…
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