00:01
Okay, so we want to create the following compounds from the given start material.
00:03
And in the first one, we're starting with aceto -phenone.
00:10
And we want to create the structure.
00:18
So we want to add two more carbons to the chain, and reacting with a strong base is going to depurtenate the alpha hydrogen.
00:24
This is going to attack an aquilide.
00:27
So we need a two -carbon aquilid, go to spread the living group, and we get our products.
00:33
And 4b, we're starting with a 4 -carbon di -keto ester, and we're going to create this.
00:53
So we can get a six carbon chain from a 1 -5 di -keyton arrangement.
01:06
So we're going to modify the structure to get a 1 -5 di -keyton arrangement using the microreaction.
01:14
So we're first going to deprotanyate the structure with sodium -thoxide.
01:20
This will be the michael donor and reacting with the michael acceptor and alpha -beta unsaturated ketone.
01:26
So this is 1, 2, 3, 4, 5, and 6.
01:33
Right now we have the structure.
01:40
So carbon 2 is bound to this 4 carbon chain.
01:48
And we're going to we're going to deprottenate this again with sodium dioxide.
01:59
So it's going to grab this hydrogen.
02:01
We've got a carbane iron here.
02:03
And this will attack the carbonyl carbon.
02:06
So again, this is 1, 2, 3, 5, and 6.
02:17
Okay, so carbon 5 is a ketone.
02:20
And same with carbon 1.
02:23
Carbon 2.
02:25
Is 5, 6, 1, carbon 2 is bound to this group right here.
02:42
And so if we redraw this, we actually have we won.
02:50
We just need to reduce some of the groups.
03:01
So we need to get rid of the ketone and turn the keto ester into a two carbon alkan.
03:09
And we can use wolfkistner reduction to reduce the ketone, and it'll turn the keto ester into a carbopstock acid.
03:19
So this is going to be an h2 with potassium hydroxide and heat.
03:38
I'm sorry, hold on.
03:39
We first want to protect the one ketone.
03:42
So we're going to use ethylene glycol.
03:46
So this is three.
03:50
So using ethylene glycol.
03:55
And then five is going to be wolfkitchen reduction.
04:01
And this is done with potassium hydroxide and heat.
04:07
So we're going to get this structure.
04:16
So we draw down here.
04:24
So the keto ester is now a carbonsulc acid, and the one ketone is gone.
04:28
We just have hydrogen here...