Disease Summary Question 1. If leptin inhibits neuropeptide Y, is appetite stimulated or suppressed? Explain how leptin and Neuropeptide Y interact.
Disease Summary Question 2. If leptin inhibits agouti-related protein, is appetite stimulated or suppressed?
Diagnosis: Clinical Manifestations and Laboratory Tests
No specific diagnostic criteria for obesity have been established. In most patients, however, the presentation is straightforward with the patient indicating problems with weight or repeated failure in achieving a sustained weight loss. In other cases, the subject may present with risk factors and/or complications of obesity. Both a medical history and physical examination are important.
Historical information is obtained about age of onset, recent weight changes, family history of obesity, eating and activity/exercise patterns, alcohol use, emotional stress level, previous weight loss experiences, and psychosocial factors, including an assessment for depression