DNA licensing in eukaryotes Group of answer choices A. synchronizes replication initiation at multiple origins. B. removes nucleosome histone proteins prior to DNA replication. C. ensures that DNA is only copied once at each origin of replication. D. A and C only. E. A, B, and C.
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Madhur L.
In eukaryotic DNA replication, the prereplication complex (preRC) assembles at the origin of replication, which contains specific nucleic acid sequences called TTTTTATG/ATTTA. Multiple protein components must assemble, including the origin recognition complex (ORC), MCM helicase, and other proteins. When all components of the preRC are bound, this completes a process called replication licensing. This process is important because it helps ensure that all origins of replication on all the chromosomes are ready to begin replication at the same time.
Keemin L.
How does replication licensing ensure that DNA is replicated only once at each origin per eukaryotic cell cycle?
Adi S.
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