Elevation of cAMP levels in bronchial smooth muscle causes: Question 3 options: Decreased phosphorylation of myosin light chain kinase Increased phosphorylation of myosin light chain kinase Increased intracellular Ca2+ levels Increased phosphorylation of myosin light chain
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Step 1: Elevation of cAMP levels in bronchial smooth muscle activates protein kinase A (PKA). Show more…
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Phosphorylation of myosin light-chain kinase (MLCK) by protein kinase $A(P K A)$ inhibits $M L C K$ activation by $\mathrm{Ca}^{2+}$ -calmodulin. Drugs such as albuterol bind to $\beta$ -adrenergic receptor, which causes a rise in cAMP in cells and activation of PKA activity. Explain why albuterol is useful for treating the severe contraction of the smooth muscle cells surrounding airway passages involved in an asthma attack.
Shveta P.
Phosphorylation of myosin light-chain kinase (MLC kinase) by protein kinase A (PKA) inhibits MLC kinase activation by $\mathrm{Ca}^{2+} / \mathrm{calmodulin.}$ Drugs such as albuterol bind to the \beta-adrenergic receptor, which causes a rise in cAMP in cells and activation of PKA. Explain why albuterol is useful for treating the severe contraction of the smooth muscle cells surrounding airway passages involved in an asthma attack.
Sri K.
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