Encephalopathy and liver damage in children, linked to aspirin use following an acute viral illness is known as: Crohn disease Huntington disease Creutzfeldt-Jacob disease Tourette syndrome Reye syndrome
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Asma V.
nonsteroidal anti-inflammatory drug (NSAID) may cause Reye's syndrome in children with viral illnesses or fever? • acetaminophen • meloxicam • aspirin • celecoxib
Hubert A.
The patient was a 6-month-old male who presented with a 3-day history of increasing hypotonia and a 1-day history of dehydration. Three days prior to admission, the mother had noticed decreased suck while breastfeeding. The next day, it took him 1 hour to take his normal amount of breast milk. He normally only took 15 minutes. During the evening 2 days prior to admission, the parents noticed the infant had generalized weakness with decreased movement and difficulty sitting up. That evening the child would not breastfeed. The morning prior to admission, the parents noted the infant was increasingly floppy and took only 1 oz of breast milk (versus the usual 4 ½ oz) and 1 oz of juice. He had trouble with gurgling in the back of his throat, very poor head control, and increased floppiness. They took him to a local physician, who noted severe hypotonia and dehydration. The parents were told to take their son to the local emergency room. On review of systems, it was noted that the child began to be constipated 4 weeks previously and had had only two small stools over the last 6 days. His diet consisted of breast milk, occasional sweet potatoes, and rice cereal. Abnormal findings on the physical exam consisted of generalized hypotonia with head lag. Cerebrospinal fluid (CSF) findings were within normal limits. The patient was admitted to the pediatric intensive care unit (PICU). Because of increasing respiratory difficulty, he was intubated. He remained on the ventilator for 6 days, was extubated, and was discharged to home 11 days after admission. What is the condition this child has? What clinical clues are present which help you make this diagnosis? What is the organism causing this condition? Briefly describe the epidemiology and pathogenesis of this disease? How is the laboratory diagnosis of this disease made? How is this form of the disease typically treated? What other forms of disease can be seen with this organism? Describe the similarities and differences in these different forms of the disease? Why is there increased concern about this organism among governmental agencies, such as the Department of Defense, the Centers for Disease Control and Prevention, and the Federal Bureau of Investigation?
Madhur L.
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