Epinephrine initiates a signal transduction pathway that...

Epinephrine initiates a signal transduction pathway that produces cyclic AMP (cAMP) and leads to the breakdown of glycogen to glucose, a major energy source for cells. But glycogen breakdown is only part of the fight or flight response that adrenaline brings about. The overall effects on the body include an increase in heart rate and alertness, as well as a burst of energy. Given that caffeine blocks the activity of cAMP phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened alertness and sleeplessness.

Transcript

00:01 So welcome back to this video.

00:05 You need to understand that before you start answering the question, you need to understand that caffeine found in coffee, you normally are a fan of coffee.

00:20 I don't know if you are a person, but i do love coffee so much.

00:25 So at times we tend to be awake, in a way, exceed awareness.

00:33 This is sleeplessness and you're very alert.

00:40 At all times, okay? due to the product goes called caffeine in coffee.

00:51 But all the mechanism behind this thing, we do get to a very important chemical, non -acrhicic, amp.

01:02 What is the mechanism behind this sleeplessness? you need to understand that caffeine has the ability to pass to the brain, passes, caffeine passes to the brain, because it has a similar structure to a molecule known as adenocene, and this is responsible for sleep.

01:41 So which means if we take caffeine, the mechanisms that are involved are going to block adenosine.

01:52 And blocking adenosine means you're deriving sleep you know you're preventing sleep and promoting alertness so what happens is that once you ingest caffeine normally we have a process of glycogen synthesis breakdown glycogen breakdown in the system but once you ingests caffeine from coffee you want to prevent you're going to prevent prevent glycogen breakdown in the body because basically caffeine inhibits a process called like amp breakdown okay did the variety of mechanism there which also means that the effects of this camp breakdown are prolonged and which are amplified all over the body so the effects activates a very important neurotransmitter chemical substance known as epineapherine epine alongside hormone known as adrenaline adrenaline adrenaline okay adrenaline or yeah so this hormone we know that it increases it increases heart rate, blood supply to vital organs and muscle contraction.

03:59 So these are all together mechanisms, heart rate, we see muscle contraction, and these are collectively known as flight and fight mechanisms which actually makes one to stay be a lot and probably lack sleep...

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