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Ester Synthesis In today's lab, you will perform small scale Fischer esterifications to make a variety of esters. R\(\text{C}(\text{O})\text{OH}\) \( + \) R'OH \(\xrightarrow{\text{H}_2\text{SO}_4} \) R\(\text{C}(\text{O})\text{OR'}\) Combinatorial chemistry is a term used to describe small scale reactions, where in a large number of different molecules can be made using the same reaction conditions, by varying the reactants. In the case of Fischer esterifications, one can vary the carboxylic acid and keep the alcohol constant or keep the carboxylic acid constant and vary the alcohol. Esters are often notable for their fragrance; as you synthesize each ester, you will take note of its particular odor (none of them are nasty, we promise). You will synthesize a total of five different esters from three carboxylic acids and four alcohols. Pre-lab Questions: 1. Show the products of the reaction below. OH +\(\text{H}_2\text{SO}_4\) OH

          Ester Synthesis
In today's lab, you will perform small scale Fischer esterifications to make a variety of esters.
R\(\text{C}(\text{O})\text{OH}\) \( + \) R'OH \(\xrightarrow{\text{H}_2\text{SO}_4} \) R\(\text{C}(\text{O})\text{OR'}\)
Combinatorial chemistry is a term used to describe small scale reactions, where in a large
number of different molecules can be made using the same reaction conditions, by varying
the reactants. In the case of Fischer esterifications, one can vary the carboxylic acid and
keep the alcohol constant or keep the carboxylic acid constant and vary the alcohol.
Esters are often notable for their fragrance; as you synthesize each ester, you will take note of
its particular odor (none of them are nasty, we promise). You will synthesize a total of
five different esters from three carboxylic acids and four alcohols.
Pre-lab Questions:
1. Show the products of the reaction below.
OH
+\(\text{H}_2\text{SO}_4\)
OH

Ester Synthesis
In today's lab, you will perform small scale Fischer esterifications to make a variety of esters.
RC(O)OH + R'OH H2SO4 RC(O)OR'
Combinatorial chemistry is a term used to describe small scale reactions, where in a large
number of different molecules can be made using the same reaction conditions, by varying
the reactants. In the case of Fischer esterifications, one can vary the carboxylic acid and
keep the alcohol constant or keep the carboxylic acid constant and vary the alcohol.
Esters are often notable for their fragrance; as you synthesize each ester, you will take note of
its particular odor (none of them are nasty, we promise). You will synthesize a total of
five different esters from three carboxylic acids and four alcohols.
Pre-lab Questions:
1. Show the products of the reaction below.
OH
+H2SO4
OH

Added by Christopher B.

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