Explain the biological basis for the law Mendel second with regards to two genes that are far apart on the same chromosome
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Distinguish how does the Law of Independent Assortment explains gametic combinations when two genes are close together on the same chromosome vs genes that occur on different chromosomes?
Josee P.
In paragraph form (-1 point if not), [A] name and define Mendel's second Law (your textbook refers to this as Mendel's second key discovery). Then explain the biological basis for this law with regards to [B] genes on different chromosomes and [C] for genes far apart on the same chromosome. In both cases [B and C], describe the relevant portions of meiosis. Lastly [D], outline why genes close together on the same chromosome might not appear to follow Mendel's second law.
Katlin K.
One of the standard techniques to determine whether two loci are physically close to one another on the same chromosome is to conduct a "dihybrid cross", a cross of two individuals that are heterozygous at both loci. For example, if the two loci have alleles A and a at the first locus and B and b at the second locus then crossing two AaBb individuals (where the capital alleles are known to be on the same chromosome) is performed. If the loci are not close to one another (or are on different chromosomes) then the expected frequencies of the gametes would be 1/4 AB, 1/4 Ab, 1/4 aB and 1/4 ab - leading to expected frequencies of 1/16 for each of the possible gamete combinations in the offspring. The genetics model that makes these predictions is the "model of independent assortment." Consider the following situation. At the first locus AA homozygotes are Black while aa homozygotes are white and the A allele is dominant to the a allele. At the second locus BB individuals are large while bb individuals are small and Bb individuals are intermediate in size. An experiment is conducted in which two AaBb heterozygotes are crossed to produce numerous offspring with phenotypes in the following numbers. Observed Black large 293 Black intermediate 684 Black small 275 White large 122 White intermediate 230 White small 96
Adi S.
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