Question

First step Pyruvate reacts with TPP and is decarboxylated, forming hydroxyethyl-TPP. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide. FADH$_2$ is reoxidized to FAD, reducing NAD$^+$ to NADH. The lipoamide arm moves to the active site of E3, where the reduced lipoamide is oxidized by FAD, forming the active lipoamide and FADH$_2$. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide. Last step

          First step
Pyruvate reacts with TPP and is decarboxylated, forming hydroxyethyl-TPP.
The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the
acetyl group to the lipoamide.
FADH$_2$ is reoxidized to FAD, reducing NAD$^+$ to NADH.
The lipoamide arm moves to the active site of E3, where the reduced lipoamide is
oxidized by FAD, forming the active lipoamide and FADH$_2$.
The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is
transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.
Last step

first step pyruvate reacts with tpp and is decarboxylated forming hydroxyethyl tpp the lipoamide arm of e2 moves to the active site of e1 enabling the transfer of the acetyl group to the lip 10297

Added by Jillian A.

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