Follow the five steps below to complete the cancerous signaling pathway in the “Q25 Cancerous Pathway” sheet of your CB Act 2 Workbook: ● Copy the orange GF-L symbol and place it at the active site of the appropriate receptor. ● Copy the yellow phosphorylation symbol and add it to all phosphorylated proteins activated in the presence of GF-L. ● Copy the black activation arrows and place them between proteins that activate each other in the presence of GF-L. ● Copy the red inhibition symbols and place them between the correct protein that inhibits each other in the presence of GF-L. ● Copy the final activation arrow and add it to the correct locations where proteins directly promote cell division in the presence of GF-L.
Added by Daniel W.
Step 1
Identify the receptor that is activated by the growth factor ligand (GF-L) and position the orange symbol accordingly. Show more…
Show all steps
Your feedback will help us improve your experience
Adi S and 88 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Looking at Figure 26-19 and the description of Wnt signaling in your textbook, can you draw the regulatory relationships between the following Wnt pathway signaling molecules? Use arrows to indicate activation and "T"s to indicate inhibition: Axin Frizzled Wnt GSK ̠-catenin APC (note that this is a scaffolding protein which does not actually activate or inhibit; what is relevant here is whether APC appears to activate or inhibit the pathway if mutated) Cell growth
Adi S.
Cell development, motility, immune function, and many other biochemical processes are controlled by growth factor receptors. Growth factors act through a common series of signaling steps. Place the steps shown in the correct order from first to last: Order of Growth Factor Signals: 1. Growth factor binds to inactive receptor. 2. The kinase receptor domain will recognize tyrosines on the SH2 binding partners, phosphorylating these motifs. 3. Receptor dimerizes (some receptors are already a dimer in the inactive state). 4. SH2 domain-containing proteins will bind to the receptor at the phosphorylated tyrosine residue. 5. The intracellular kinase domain in the receptor recognizes and will autophosphorylate the dimer partner at a tyrosine. Final GF Signaling:
Madhur L.
Deregulated epidermal growth factor (EGF) signaling has been implicated in diverse cancer types, including colon and breast cancer. As such, ongoing efforts are focused on developing therapeutic agents targeting the pathway. (4 points) Draw a pathway diagram of EGFR signaling in cancer cell proliferation and migration. (3 points) List one key mutation (amino acid changes) in EGFR, k-RAS, and b-RAF that are prevalent in cancer. (3 points) Discuss the functional consequences of each mutation in 1b.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD