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4. Cystic fibrosis is one of the most common autosomal recessive diseases in people of Northern European descent. A mutation in the CF gene affects a protein involved in the transport of chloride and sodium across cell membranes, causing thick mucus and secretions, lung damage, and nutritional deficiencies. The disease is inherited in an autosomal recessive manner, meaning one must inherit two mutated alleles in order to have the disease. Greg does not have cystic fibrosis, and there is no family history of the disease. His wife Sally also does not have cystic fibrosis, but her sister does. As a genetic counselor, what would you tell Greg and Sally about the probability of their children inheriting cystic fibrosis? In your explanation, include the possible genotypes for both Greg and Sally. 5. Sickle cell anemia is inherited via incomplete dominance. The allele A encodes the normal hemoglobin protein. Individuals with the genotype AA will have normal hemoglobin. The allele S encodes the abnormal hemoglobin protein. Individuals with the genotype SS produce only the abnormal hemoglobin protein and have sickle cell anemia. Individuals with the AS genotype produce both the normal and abnormal forms of hemoglobin. They have the sickle cell trait and have RBCs that only sickle in extremely low oxygen environments. The presence of the sickle cell hemoglobin allele (S) also provides resistance to malaria. A man and woman living in a tropical area where malaria is prevalent and health care is inaccessible have five children. Their genotypes are SS, AS, AS, SS, and AA. a. What are the genotypes of the parents? b. What kinds of gametes can the mother produce? c. What kinds of gametes can the father produce? d. Why would children who are AS be most likely to live to adulthood and reproduce?

4. Cystic fibrosis is one of the most common autosomal recessive diseases in people of Northern European descent. A mutation in the CF gene affects a protein involved in the transport of chloride and sodium across cell membranes, causing thick mucus and secretions, lung damage, and nutritional deficiencies. The disease is inherited in an autosomal recessive manner, meaning one must inherit two mutated alleles in order to have the disease. Greg does not have cystic fibrosis, and there is no family history of the disease. His wife Sally also does not have cystic fibrosis, but her sister does. As a genetic counselor, what would you tell Greg and Sally about the probability of their children inheriting cystic fibrosis? In your explanation, include the possible genotypes for both Greg and Sally.

5. Sickle cell anemia is inherited via incomplete dominance. The allele A encodes the normal hemoglobin protein. Individuals with the genotype AA will have normal hemoglobin. The allele S encodes the abnormal hemoglobin protein. Individuals with the genotype SS produce only the abnormal hemoglobin protein and have sickle cell anemia. Individuals with the AS genotype produce both the normal and abnormal forms of hemoglobin. They have the sickle cell trait and have RBCs that only sickle in extremely low oxygen environments. The presence of the sickle cell hemoglobin allele (S) also provides resistance to malaria.

A man and woman living in a tropical area where malaria is prevalent and health care is inaccessible have five children. Their genotypes are SS, AS, AS, SS, and AA.
a. What are the genotypes of the parents?
b. What kinds of gametes can the mother produce?
c. What kinds of gametes can the father produce?
d. Why would children who are AS be most likely to live to adulthood and reproduce?

4. Cystic fibrosis is one of the most common autosomal recessive diseases in people of Northern European descent. A mutation in the CF gene affects a protein involved in the transport of chloride and sodium across cell membranes, causing thick mucus and secretions, lung damage, and nutritional deficiencies. The disease is inherited in an autosomal recessive manner, meaning one must inherit two mutated alleles in order to have the disease. Greg does not have cystic fibrosis, and there is no family history of the disease. His wife Sally also does not have cystic fibrosis, but her sister does. As a genetic counselor, what would you tell Greg and Sally about the probability of their children inheriting cystic fibrosis? In your explanation, include the possible genotypes for both Greg and Sally.

5. Sickle cell anemia is inherited via incomplete dominance. The allele A encodes the normal hemoglobin protein. Individuals with the genotype AA will have normal hemoglobin. The allele S encodes the abnormal hemoglobin protein. Individuals with the genotype SS produce only the abnormal hemoglobin protein and have sickle cell anemia. Individuals with the AS genotype produce both the normal and abnormal forms of hemoglobin. They have the sickle cell trait and have RBCs that only sickle in extremely low oxygen environments. The presence of the sickle cell hemoglobin allele (S) also provides resistance to malaria.

A man and woman living in a tropical area where malaria is prevalent and health care is inaccessible have five children. Their genotypes are SS, AS, AS, SS, and AA.
a. What are the genotypes of the parents?
b. What kinds of gametes can the mother produce?
c. What kinds of gametes can the father produce?
d. Why would children who are AS be most likely to live to adulthood and reproduce?

Added by Aaron K.

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