00:01
An uncorrected mistake in dna is what we call a mutation.
00:06
And so what we're going to look at here is a strand of dna that has had this mutation occur, which encodes for sickle cell hemoglobin here.
00:15
So first thing i'm going to do is take our dna to mrna.
00:20
So what we have to remember about this is just like in dna replication, c is going to pair with g.
00:28
But our difference here is that instead of thymine, which usually pairs with a, and mrna, we have uracil.
00:36
So essentially we're just going to go down our code, our strand here, and just keep matching up our letters.
00:43
And there we have our corresponding mrna sequence.
00:47
Then in order to find our polypeptide sequence, we're going to divide each of the, or the mrna strand into groups of three called codons.
00:58
And then use our fancy codon chart to find what the corresponding amino acids are.
01:05
So, aug, methyane, gug, valin, cac, histidine, so on and so forth, all the way down the strand.
01:16
Now we have our sickle cell dna sequence here, which it's very similar up until we get to this one mutation...