Germinal centers are necessary for the formation of Question 2 options: Mast Cells Pea plants Neutrophils Complement B memory cells
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Germinal centers are specialized structures within lymphoid tissues where B cells proliferate, differentiate, and undergo somatic hypermutation and class switching. Show more…
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Which of the following is described as the intermediate form of B cells where they secrete antibody but retain substantial surface immunoglobulin and MHC class II molecules and so can continue to take up and present antigen to T cells? plasmablasts memory cells plasma cells erythrocytes Question 11 0.2 pts The germinal center is a region within the secondary B cell follicle where sustained B cell proliferation and differentiation take place. The processes of B cell proliferation and differentiation, including affinity maturation and class switching, require periodic interactions of the germinal center B cells with CD4 TFH cells. These periodic interactions between the B cells and TFH cells can occur: When B cells cycle between the dark zone and the light zone of the germinal center When B cells migrate and form a primary focus of antibody-secreting plasmablasts in the medullary cords of the lymph node When B cells leave the germinal center and migrate through the T-cell zone on their way to the blood When B cells migrate to the border between the T-cell zone and the B-cell zone of the lymph node When B cells up-regulate CXCR4 and migrate into the dark zone of the germinal center
Adi S.
Which of the following is not characteristic of B cells? differentiate into macrophages responsible for production of serum antibody originate in bone marrow retain "memory" for various antigens increase in number upon antigen presentation
Qudsiya A.
Fill in the blank(s) in each statement below with the most appropriate term(s) from the following list. Terms may be used more than once or not at all. Dark zone Light zone Cortex Centroblasts Centrocytes Follicular dendritic cells Medullary cords Memory B cells Plasma cells Isotype switch TFH cells Primary focus 1. Most centrocytes die by apoptosis in the dark zone. 2. Initial activation of naïve B cells induced by thymus-dependent antigen occurs in the cortex within primary focus. 3. Centroblasts are rapidly dividing cells located in the dark zone of the germinal centers. 4. Centrocytes expressing high affinity receptor interact with antigen captured by follicular dendritic cells in the light zone. 5. Class switching occurs in the cortex and requires direct contact between B cells and TFH cells. 6. Centrocytes expressing receptors specific for self antigen present in bone marrow are subjected to negative selection in the cortex. 7. Within lymph nodes, plasma cells are found primarily in the medullary cords of secondary follicles. 8. Somatic hypermutation, which occurs in proliferating centroblasts, is critical for affinity maturation. 9. X-linked hyper-IgM syndrome results from a defect in CD-40 ligand on T cells, which affects B cells by blocking isotype switch. 10. Mature plasma cells produce large amounts of soluble IgG.
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