00:01
So on the board, it shows a pathway.
00:04
Basically, you have a apc -c complex.
00:10
Now, it is actually interact with cdc -20.
00:17
So after it forms a complex, obviously, apc -c is being activated.
00:35
The activated complex is going to work on the complex that formed between the securing and separates.
01:01
So the activated complex is going to ubiquitinate the securing, so the separates will be free.
01:11
So by there, we know that in during g2 phase, you have the cohesin complex between the sister chromatids.
01:24
So these are the protein complex called cohesin.
01:30
Now, obviously, the two sister chromatids stay together because of cohesin.
01:37
So during metaphase, you can see that the two sister chromatids still stay together because the cohesin complex.
01:48
Now, once the apc -c complex is being activated by cdc -20 and securing is being ubiquitinated and the free separates is going to actually work on these cohesin complex, and then the cohesin will be degraded.
02:12
And due to the degradation, the two sister chromatids, they separate, they associate from each other.
02:19
And this moves on to anaphase.
02:24
So you can see that two sister chromatids now to become separate chromosome, and then they are being pulled away from the center of the cell and towards the opposite pole.
02:36
So this is anaphase.
02:39
So this is a normal pathway...