Group C Attempt any one 1) Explain the cisternal maturation model and vesicular transport model [5+5] 2) Explain the role of lysosome in phagocytosis [5]
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CHAPTER 8 LECTURE QUIZ FILL IN THE BLANK WITH THE CORRECT TERM. 1) The ________ is the organelle involved in the post-translational (secondary) modification of proteins and sorting of proteins to various intracellular and extracellular compartments. 2) A ________ is the organelle that fuses with endosomes and supplies hydrolytic enzymes necessary for the digestion of the materials within the endosome. 3) A ________ is a short sequence of amino acids that targets a protein for translation across the endoplasmic reticulum. 4) ________ is the molecule associated with receptor-mediated endocytosis that "coats" the vesicle until it is released. 5) ________ is the organelle associated with the functions of steroid biosynthesis, carbohydrate metabolism, and drug detoxification. MATCH THE TERM ON THE LEFT WITH ITS DEFINITION ON THE RIGHT. ___ 6) Tay Sachs disease ___ 7) COPII coated vesicle ___ 8) clathrin secretory vesicle ___ 9) endomembrane system ___ 10) receptor mediated endocytosis ___ 11) endosome ___ 12) dynamin ___ 13) endocytosis ___ 14) autophagy ___ 15) regulated secretion ___ 16) phagocytosis ___ 17) atherosclerosis ___ 18) constitutive secretion ___ 19) tonoplast ___ 20) mannose-6-phosphate a) inter-related membrane system in which the individual components function as part of a coordinated unit b) mediates transfer of lysosomal enzymes into a lysosome c) mediated by cells called neutrophils in mammals d) related to increased blood levels of LDL e) discharge of materials from the cell in a continuous fashion f) used to transport proteins from ER to Golgi g) membrane surrounding plant vacuoles h) transports proteins from Golgi to plasma membrane i) a lysosomal storage disorder j) a protein involved in the removal of vesicles from the membrane k) distribution centers along the endocytic pathway l) uptake of specific extracellular ligands following their binding to a specific receptor or protein m) process by which cells internalize receptors and extracellular ligands n) the regulated destruction of the cell's own organelles o) materials are stored and secreted only in response to an appropriate stimulus
Sri K.
9. Explain what two types of proteins are transferred from the cytosol to the ER. How are these proteins translocated into the RER? What are some examples of proteins that would fit into each of these two categories? 10. Explain the secretory and endocytic pathways. 11. Explain vesicle budding and protein coats. 12. Explain the basic role of SNARES in vesicle docking. 13. Explain the types of covalent modifications of proteins in the ER and Golgi. Relate these modifications to concepts we have discussed, i.e. di-sulfide bonds. 14. Explain the constitutive and regulated pathways from the Golgi. Include some examples of proteins that would use each pathway. 15. Explain the basics of receptor-mediated endocytosis. 16. Explain the mannose-6-phosphate tag for the enzyme delivery to lysosomes.
Josee P.
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