Having the secondary andor tertiary structure of a protein...

having the secondary and/or tertiary structure of a protein disrupted, while leaving the amino acid sequence unchanged. Such proteins can no longer perform their biological functions. allosteric regulation competitive inhibition coupling denaturation feedback inhibition non-competitive inhibition

Transcript

00:01 To answer this question, let us first understand enzyme action mechanism.

00:09 That is how enzyme works.

00:13 So consider there is an enzyme.

00:26 Now, this enzyme has one active side.

00:29 This is called as active side.

00:33 Let us draw the substrate.

00:36 If this is the substrate.

00:40 A substrate almost fixed to the enzyme form a...

00:46 Enzyme substrate complex so it will and this if this is the substrate it fits to the enzymes active side to form enzyme substrate complex so here the substrate will fit now this is called this phase is called as enzyme substrate complex and this enzyme substrate complex will form the products so it will form the enzyme product complex in this let us draw products with so this is called as enzyme products complex because substrate using the enzymes active side they join and then they transform into the products or enzyme product complex and after this they will leave the enzymes because as we know that enzymes don't change while forming the products they are only used to catalyze the reaction so products will be removed out leaving the active side as it is for the new other reactions so these are the products and now enzyme is separated and products are separated in this case enzymes are separated and the substrate is different now as we have understood the mechanism let us now see that why enzymes are inactive when the proteins are denatured so during the three -dimensional structure of proteins they have active sites these three dimensional structure have active sides and these active sites are necessary for their activity for the enzyme activity.

03:28 But when these protein structure are changed due to any non -physiological ph or any heat, these active sites will change...

Question

having the secondary and/or tertiary structure of a protein disrupted, while leaving the amino acid sequence unchanged. Such proteins can no longer perform their biological functions. allosteric regulation competitive inhibition coupling denaturation feedback inhibition non-competitive inhibition

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