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Rob L. a 28-year-old male, complained of abrupt polydipsia (excessive thirst) and polyuria (excessive urine volume) . Blood and urine analyses provided the following results: Serum potassium 2.8 mEq/L, Serum sodium 145 mmol/L, Fasting blood glucose 93 mg/dL. Water deprivation and hypertonic saline infusion did not cause a significant reduction in the polyuria nor did the urine become more concentrated. Complete water-deprivation resulted in a urine osmolarity 225 mOsm/L. Following administration of exogenous ADH, there was a significant concentration of the urine and a decrease in urinary output. 1. How would a normal healthy person respond to these tests? Think of how urine volume and concentration would be affected. 2. Why did the water deprivation and hypertonic saline infusion not result in a concentrated urine? 3. Are Rob's kidneys capable of responding to ADH? What is the evidence? 4. What is the name of this endocrine disorder? 5. Is there a defective endocrine gland? If so, which is it?

          Rob L. a 28-year-old male, complained of abrupt polydipsia (excessive thirst) and polyuria (excessive urine volume) . Blood and urine analyses provided the following results: Serum potassium 2.8 mEq/L, Serum sodium 145 mmol/L, Fasting blood glucose 93 mg/dL. Water deprivation and hypertonic saline infusion did not cause a significant reduction in the polyuria nor did the urine become more concentrated. Complete water-deprivation resulted in a urine osmolarity 225 mOsm/L. Following administration of exogenous ADH, there was a significant concentration of the urine and a decrease in urinary output. 1. How would a normal healthy person respond to these tests? Think of how urine volume and concentration would be affected. 2. Why did the water deprivation and hypertonic saline infusion not result in a concentrated urine? 3. Are Rob's kidneys capable of responding to ADH? What is the evidence? 4. What is the name of this endocrine disorder? 5. Is there a defective endocrine gland? If so, which is it?

Rob L. a 28-year-old male, complained of abrupt polydipsia (excessive thirst) and polyuria (excessive urine volume) . Blood and urine analyses provided the following results: Serum potassium 2.8 mEq/L, Serum sodium 145 mmol/L, Fasting blood glucose 93 mg/dL. Water deprivation and hypertonic saline infusion did not cause a significant reduction in the polyuria nor did the urine become more concentrated. Complete water-deprivation resulted in a urine osmolarity 225 mOsm/L. Following administration of exogenous ADH, there was a significant concentration of the urine and a decrease in urinary output. 1. How would a normal healthy person respond to these tests? Think of how urine volume and concentration would be affected. 2. Why did the water deprivation and hypertonic saline infusion not result in a concentrated urine? 3. Are Rob's kidneys capable of responding to ADH? What is the evidence? 4. What is the name of this endocrine disorder? 5. Is there a defective endocrine gland? If so, which is it?

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