Question

Hemoglobin: Allostery and Evolution Q5.1 - 2,3-BPG is a negative allosteric regulator of hemoglobin (Hb) oxygen binding. Explain how elevated levels of 2,3-BPG in red blood cells at high altitude (14,800 ft above sea level) lead to more efficient delivery of O2 to the tissues considering that less O2 binds to Hb in the lungs under these conditions. Membrane Transport Proteins Q5.2 - What explains the 10,000 to 1 selectivity of the potassium channel for K+ over Na+ considering that the atomic radii of these two ions differ by only 0.4 Angstroms. The Actin-Myosin Motor Q5.3 - What biochemical process must occur in the myosin head to initiate the "power stroke" in muscle contraction, which is characterized by a large protein conformational change? What conformational change is associated with ATP hydrolysis?

          Hemoglobin: Allostery and Evolution
Q5.1 - 2,3-BPG is a negative allosteric regulator of hemoglobin (Hb) oxygen binding. Explain how elevated levels of 2,3-BPG in red blood cells at high altitude (14,800 ft above sea level) lead to more efficient delivery of O2 to the tissues considering that less O2 binds to Hb in the lungs under these conditions.
Membrane Transport Proteins
Q5.2 - What explains the 10,000 to 1 selectivity of the potassium channel for K+ over Na+ considering that the atomic radii of these two ions differ by only 0.4 Angstroms.
The Actin-Myosin Motor
Q5.3 - What biochemical process must occur in the myosin head to initiate the "power stroke" in muscle contraction, which is characterized by a large protein conformational change? What conformational change is associated with ATP hydrolysis?

Added by Lisa B.

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