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Hemophilia is a sex-linked hereditary blood defect of males characterized by delayed clotting of the blood which makes it difficult to control bleeding, even in the case of a minor injury. When a woman is a carrier of classical hemophilia, there is a 50% chance that a male child will inherit the disease. If a carrier gives birth to two sons, what is the probability that both boys will have the disease? What approach to probability are you using to answer this question?

          Hemophilia is a sex-linked hereditary blood defect of males characterized by delayed clotting of the blood which makes it difficult to control bleeding, even in the case of a minor injury. When a woman is a carrier of classical hemophilia, there is a 50% chance that a male child will inherit the disease. If a carrier gives birth to two sons, what is the probability that both boys will have the disease? What approach to probability are you using to answer this question?
        
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Biology for AP Courses
Biology for AP Courses
Julianne Zedalis, John Eggebrecht
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Hemophilia is a sex-linked hereditary blood defect of males characterized by delayed clotting of the blood which makes it difficult to control bleeding, even in the case of a minor injury. When a woman is a carrier of classical hemophilia, there is a 50% chance that a male child will inherit the disease. If a carrier gives birth to two sons, what is the probability that both boys will have the disease? What approach to probability are you using to answer this question?
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Hemophilia is a sex-linked trait where XH gives normal blood clotting and is dominant to the hemophilia allele Xh. Males that are XHY are normal, but males that are XhY are hemophiliacs. For women: XHXH are normal (unaffected); XHXh are normal but carry the allele (carriers); XhXh have hemophilia (are affected). 1. What is the genotype for Angelina with normal blood clotting whose father had hemophilia? 2. What is the genotype for Brad with normal blood clotting whose father had hemophilia? 3. Cross Angelina and Brad. What are Angelina's possible gametes? 4. Cross Angelina and Brad. What are Brad's possible gametes? 5. What is the probability that a mating between these two individuals will produce a child, regardless of sex, that has hemophilia? (Give a percentage.) 6. If this couple has a daughter, what is the probability that the daughter will be a carrier (carries a copy of the normal allele and hemophilia allele) of the hemophilia trait? 7. If this couple has a daughter, what is the probability that the daughter would have hemophilia? 8. If this couple has a son, what is the probability he will have hemophilia?

Madhur L.

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3. Hemophilia is a sex-linked trait where XH gives normal blood clotting and is dominant to the hemophilia allele, Xh: a. Give the genotype of a woman with normal blood clotting whose father had hemophilia b. Give the genotype of a man with normal blood clotting whose father had hemophilia c. What is the probability that a mating between these two individuals will produce a child of any sex that has hemophilia? d. If this couple has a daughter, what is the probability that she will be a carrier of the hemophilia trait? e. If this couple has a son, what is the probability that he will have hemophilia? 4. Clouded leopards can have normal (XN) or dark (Xn) spots. Normal spots are dominant to dark spots and the trait is X-linked. A male clouded leopard with dark spots is bred with a female with normal spots as part of a conservation biology program. This mating produces 4 cubs, 2 male and 2 female. One each of the male and female cubs has normal spots and one each have dark spots. What is the genotype of the mother?

Bryan V.


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Transcript

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00:01 You had several questions about blood types.
00:03 So i'm going to roll through them, and i'm going to show you some examples and show you how to approach these different types of questions.
00:09 So first off, we're going to look at the information that's given.
00:12 We are told that you could have a few different blood types, and we're going to look at multiple different things here.
00:17 So if a and b are both dominant alleles for blood types, so if you have at least one allele for a, you'll have type a, blood.
00:32 If you have at least one for b, you'll have type b blood.
00:35 But because they're both dominant and they're sort of co -dominant, if you have one a and one b, you'll actually have type a -b blood.
00:46 But if you have neither of those, if you have the recessive, just plain eyes, then you'll have type o blood.
00:53 And then you could be rh positive if you have at least one dominant r -h -alele.
01:00 And if you do not have any dominant alleles, you'll be rh negative.
01:06 And then the l -m -n -n locus is pretty self -explanatory.
01:13 They are co -dominate.
01:14 So if you have two amyles, you'll present with type m.
01:17 If you have two ns, it's type n.
01:19 And again, codominance, if you have one of each, you'll have l -m -n.
01:30 You have a series of questions where you are given a cross and you're told you're asked what type of phenotypes and genotypes could you receive from that cross.
01:45 So i'm going to do the first one to show you what is expected and how to do that.
01:50 So this is the cross that we're doing.
01:53 In order to do it, you need to make a 4x4 cross because it's going to be a die hybrid cross.
02:00 Then we're going to look at all of the possible allele combinations you could get from either parent.
02:05 So for this first parent, we could have the first allele with the first r allele.
02:11 So you could get a and r.
02:16 You could get the first allele with the second r allele, a and lowercase r, that little i allele with the first r allele or the little i allele with the second r allele.
02:32 And so you'll do that same process with the second person, all of the possible combinations.
02:39 And then you would just complete the cross as normal.
02:50 Once you complete it, you can see that it's a fairly simple cross because one of our people had the same blood type alleles and the same r's alleles.
03:01 So then you can break it down and find all of the different phenotypes, whether they're a positive, a minus b positive, b negative, a b positive, a, b negative.
03:15 So you can see in this first column, it is all ab, and then they have one dominant r -h allel, so they are ab -positive, so there's four of those.
03:27 In the second column, they're all the same again.
03:30 And you see ab, but no dominant r, so they're all ab -negative.
03:36 Next column, again, they're all the same.
03:39 Like i said, this is an easy cross.
03:40 So they're b, there's no a, but they do have positive, so they're four b positives.
03:50 And this next one, they're all b, but they don't have the positive, so they are b negative...
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